Catherine Vénien-Bryan

Many signals in the cell are conveyed by interacting protein molecules. How do protein-protein interactions lead to a response? The most likely explanation is through changes in structure. We study protein-protein interactions in the control of signalling processes using electron microscopy and combining the results with information from X-ray diffraction and biophysical studies.

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POSITION

PU UPMC

CONTACT

Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie

UPMC-Sorbonne Université, CNRS, IRD and MNHN

4, place Jussieu, 75005 Paris, France

E-mail: catherine.venien-bryan(at)upmc.fr

Research experience and positions held

2009-2012 Invited professor at the university of Oxford, Biochemistry Department

2009- : Professor UPMC, Paris

2001- 2009: Senior University Research Lecturer Biochemistry Department University of Oxford, Oxford,UK

1998-2001: Visiting Research Fellow Biochemistry Department University of Oxford, Oxford, UK

1993-1998: Lecturer in Biophysics University J. Fourier Grenoble, France

1991-1993: Post-doctoral research assistant Biochemistry Department University of

Oxford Oxford, UK, EC Bridge and Welcome Trust fellowships

1988-1990: Post-doctoral research assistant EMBL Heidelberg Germany (Structural Biology Program) DFG and EMBO fellowships

Academic Resume

-Habilitation à diriger des recherches (HDR) 1998

-PhD in Biophysics University Pierre et Marie Curie Paris6 1988

Publications

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Yang D, Wan X, Dennis AT, Bektik E, Wang Z, Costa MGS, Fagnen C, Vénien-Bryan C, Xu X, Gratz DH, Hund TJ, Mohler PJ, Laurita KR, Deschênes I, Fu JD. MicroRNA Biophysically Modulates Cardiac Action Potential via Directly Binding to Ion Channel. Circulation (2021) doi: 10.1161/CIRCULATIONAHA.120.050098. Online ahead of print. (See article)

Fagnen C, Bannwarth L, Oubella I, Forest E, De Zorzi R, Araujo A, Mhoumadi Y, Bendahhou S, Perahia D, Vénien-Bryan C. New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies. Scientific Reports (2020) 10(1):8392 (See article)

Costa MGS, Fagnen C, Vénien-Bryan C, Perahia D. A New Strategy for Atomic Flexible Fitting in Cryo-EM Maps by Molecular Dynamics with Excited Normal Modes (MDeNM-EMfit). J. Chem. Inf. Model. (2020) 60(5): 2419–2423 (See article)

Liang, CC Li Z, Lopez-Martinez, Nicholson W, Vénien-Bryan C, Cohn M. The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2. Nature Commun (2016) 7:12124 (2016) (See article)

De Zorzi R, Nicholson WV, Guigner JM, Erne-Brand F, Vénien-Bryan C. Growth of large and highly ordered 2D crystals of a K+ channel, structural role of lipidic environment. Biophys. J. 2013 105 :398-408 (See article)

Bavro VN, De Zorzi R, Schmidt MR, Muniz JR, Zubcevic L, Sansom MSP, Vénien-Bryan C, Tucker SJ X-ray Crystal structure of a KirBac potassium channel highlights a mechanism of channel opening at the bundlecrossing gate. Nature Structural & Molecular Biology (2012) 19(2) 158-63 (See article)

Sinclair J, Davies KM, Vénien-Bryan C, Noble M: Generation of protein lattices by fusing proteins with matching rotational symmetry . Nature Nanotechnology 2011.6(9):558-62 (See article)

Crozat E, Meglio A, Allemand JF, Chivers CE, Howarth M, Venien-Bryan C, Grainge I, Sherratt DJ. Separating speed and ability to displace roadblocks during DNA translocation by FtsK. Embo Journal 2010, 29:1423-1433. (See article)

Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N: The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. Proc Natl Acad Sci U S A; 2009, 106 :12712-12716. (See article)

Vénien-Bryan C, Jonic S, Skamnaki V, Brown N, Bischler N, Oikonomakos NG, Boisset N, Johnson LN. The structure of phosphorylase kinase holoenzyme at 9.9 a resolution and location of the catalytic subunit and themsubstrate glycogen phosphorylase. Structure 2009, 17:117-127 (See article)

Jonic S, Vénien-Bryan C. Protein structure determination by electron cryo-microscopy Curr Opin Pharmacol. 2009;9(5):636-42 (See article)

Davies KM, Skamnaki V, Johnson LN, Venien-Bryan C: Structural and functional studies of the response regulator HupR. Journal of Molecular Biology 2006, 359:276-288. (See article)

Kuo AL, Domene C, Johnson LN, Doyle DA, Venien-Bryan Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography. Structure 2005, 13:1463- 1472. (See article)

Passmore LA, Booth CR, Venien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Molecular Cell 2005, 20:855-866. (See article)

Learning Societes

President of the Societé Française des Microscopies (2020-2021)

Member of the Biophysical Society

Member of the Société Francaise de biophysique