François Guyot(PR MNHN)

Scientific Expertise



Geochemistry, Biogeochemistry

Chemical Thermodynamics

Mineral Physics


Contact Details


Office : Site Buffon, 2th Floor, Room 219

Telephone : 01 40 79 46 83

Mail : fguyot @

Website :

Analytical Skills

  - Electron microscopies (SEM and TEM) 

  - Crystallography (X-ray Diffraction and Absorption)

  - Geochemical Modeling (Chess)

Professional Resume


  - Since 2017: Professor of Institut Universitaire de France (IUF)

  - Since 2014: Deputy Director of IMPMC

  - Since 2013: Professor of the Muséum National d’Histoire Naturelle (MNHN Paris)

  - 1995-2013: Professor of Institut de Physique du Globe de Paris (IPGP, France) - University Paris Diderot

  - 1996-2001: Professor of Institut Universitaire de France (IUF)

  - 1994-1995: Research Fellow at the Center for High Pressure Research, Stony Brook University, New York (USA)

   - 1990-1994: CNRS Researcher in mineralogy/geochemistry at IPGP (Paris, France)

  - 1988-1990: Research Assistant at the Center for High Pressure Research, Stony Brook University, New York (USA)

  - 1986-1988: Teaching Assistant at the École Normale Supérieure (ENS Paris, France)

Educational Background

  - Habilitation à diriger des recherches (HDR) - Physical and Chemical Properties of Deep Earth Materials - 1993.

  - PhD. in Condensed Matter Physics, University Paris Curie & IPGP - 1988

  - Agregation in Physic and Chemistry Sciences - 1985


  - Total number of peer-reviewed scientific publications (August 2017): 207

  - Total number of citations in scientific journals (August 2017): 6667

  - H index (August 2017): 47

  - ResearcherID: C-3824-2016


2017 publications :

- Créon L., Rouchon V., Youssef S., Rosenberg E., Delpech G., Szabo C., Remusat L., Mostefaoui S., Asimow P.D., Antoshechkina P.M., Ghiorso M.S., Boller E., Guyot F. Highly CO2- supersaturated melts in the Pannonian lithospheric mantle – A transient carbon reservoir? Lithos 286, 519-533, 2017.

- Creon L., Delpech G., Rouchon V., Guyot F. Slab-derived metasomatism in the Carpathian-Pannonian mantle revealed by investigations of mantle xenoliths from the Balcony-Balaton Highland Volcanic Field. Lithos 286, 534-552, 2017.

- Ducasse R., Wang W.A., Navarro M.G.J., Debons N., Colin A., Gautier J., Guigner J.M., Guyot F., Gueroui Z. Programmed Self-Assembly of a Biochemical and Magnetic Scaffold to Trigger and Manipulate Microtubule Structures. Scientific Reports 7, 2017.

- Cassone G., Pietrucci F., Saija F., Guyot F., Sponer J., Sponer E., Saitta M. Novel electrochemical route to cleaner fuel dimethyl ether. Scientific Reports 7, 2017.

- Alphandery E., Idbaih A., Adam C., Delattre J.Y., Schmitt C., Guyot F., Chebbi I. Chains of magnetosomes with controlled endotoxin release and partial tumor occupation induce full destruction of intracranial U87-Luc glioma in mice under the application of an alternating magnetic field. Journal of Controlled Release 262, 259-272, 2017.

- Espinosa-Ortiz E.J., Rene E.R., Guyot F. et al. Biomineralization of tellurium and selenium-tellurium nanoparticles by the white-rot fungus Phanerochaete chrysosporium. International Biodeterioration & Biodegradation 124, 258-266, 2017.

- Hamdous Y., Chebbi I., Mandawala C., Le Févre R., Guyot F., Seksek O., Alphandéry E. Biocompatible coated magnetosome minerals with various organization and cellular interaction properties induce cytotoxicity towards RG-2 and GL-261 glioma cells in the presence of an alternating magnetic field. Journal of Nanobiotechnology 15, 2017.

- Mandawala C., Chebbi I., Durand-Dubief M., Le Févre R., Hamdous Y., Guyot F., Alphandéry E. Biocompatible and stable magnetosome minerals coated with poly-L-lysine, citric acid, oleic acid, and carboxy-methyl-dextran for application in the magnetic hyperthermia treatment of tumors. Journal of Materials Chemistry B 5(36), 7644-7660, 2017.

- Guelard J., Beaumont V., Rouchon V., Guyot F., Pillot D., Jezequel D., Ader M., Newell K.D., Deville E. Natural H-2 in Kansas: Deep or shallow origin? Geochemistry Geophysics Geosystems 18(5), 1841-1865, 2017.  

- Daval D., Bernard S., Remusat L., Wild B., Guyot F., Micha J.S., Rieutord F., Magnin V., Fernandez-Martinez A. Dynamics of altered surface layer formation on dissolving silicates. Geochimica et Cosmochimica Acta 209, 51-69, 2017.  

- Aphandery E., Idbaih A., Adam C., Delattre J.Y., Schmitt C., Guyot F., Chebbi I. Development of non-pyrogenic magnetosome minerals coated with poly-l-lysine leading to full disappearance of intracranial U87-Luc glioblastoma in 100% of treated mice using magnetic hyperthermia. Biomaterials 141, 210-222, 2017.

- Cassone G., Pietrucci F., Saija F., Guyot F., Saitta M. One-step electric-field driven methane and formaldehyde synthesis from liquid methanol. Chemical Science 8(3), 2329-2336, 2017.

- Thaler C., Millo C., Ader M., Chaduteau C., Guyot F., Ménéz B. Disequilibrium δ18O values in microbial carbonates as a tracer of metabolic production of dissolved inorganic carbon. Geochimica et Cosmochimica Acta 199, 112-129, 2017.

- Crouzet C., Brunet F., Recham N., Findling N., Lanson M., Guyot F., Ferrasse J.H., Goffe B. Hydrogen production by hydrothermal oxidation of FeO under acidic conditions. International Journal of Hydrogen Energy 42(2), 795-806, 2017.


Research InterestS and main collaborators

 (Bio)mineralogy for planetary sciences - My research has since its beginning been focused on the application of  mineralogy (i.e. the study of naturally occuring solids, of their genesis and of their interactions with their environment) and mineral physics (condensed matter physics applied to mineralogy) to important (at least in my eyes) problems of Earth and planetary sciences.

 High-pressure mineralogy of planetary interiors - My research background has been built on the study of mineralogy and properties of deep Earth. Under the impulsion of Dr Jean-Paul Poirier, I mostly applied transmission electron microscopy to the study of high-pressure diamond-anvil cell samples, then a pioneering approach, and derived from these data properties and models of the Earth lower mantle. Motivated by the discovery of thousands of exoplanets, I am still pursuing in that field of research in main collaboration with Guillaume Fiquet (ERC advanced grant PLANETDIVE).

 Biomineralization by prokaryotic microorganisms- In close collaboration with Philippe Gillet (then at ENS Lyon, France, now at EPFL, Lausanne, Switzerland) and with Karim Benzerara (then PhD student at IMPMC, now research director at IMPMC, Paris), I started to apply the very same mineral physics concepts as those used in planetology to the study of biomineralization by prokaryotic microorganisms. This was initially done in the context of finding traces of life in extreme environments with possible applications to Mars sample returns and to extra-terrestrial samples. In the recent years, I have pursued research on biomineralization mainly on iron oxides and applications of magnetotactic bacteria in collaboration with Edouard Alphandéry (IMPMC Paris and the startup Nanobacterie), Jennyfer Miot (then PhD student at IMPMC, now researcher at IMPMC Paris), and recently Zoher Gueroui (ENS Paris). I also have participated to researches about phosphate biomineralization by bacteria in collaboration with Julie Cosmidis (then PhD student at IPG/IMPMC Paris) and Karim Benzerara (IMPMC, Paris). In this field, I have initiated geochemical work on magnetotactic bacteria with Matthieu Amor (then PhD student IMPMC Paris now at UC Berkeley with Pr Arash Komeili) and Vincent Busigny (IPG Paris). I am still participating into this research with the aim of better modeling the elemental and isotope compositions of magnetites and greigites in microbial cultures and in the environment.

 Environmental biomineralogy - I have also applied the concepts of mineralogy, biomineralization and mineral physics to environmental studies, mostly focused on fundamental and applied issues in CO2 capture, storage and valorization, in collaboration with Bénédicte Menez (IPG Paris) in the framework  of the IPG, Total, Schlumberger CO2 center in Paris. This drove researches on fundamental processes at the mineral water interface that I am pursuing with Damien Daval (then PhD student at IPG Paris and ENS Paris, now researcher at LHYGES Université de Strasbourg). The new issue of finding ways of valorizing CO2 being inspired by natural processes, especially with regard of H2 generation and CO2-H2 interactions, has led me to collaborate with several researchers, mainly Isabelle Martinez (IPG Paris), Vincent Milesi (then PhD student IPG Paris now at Total), Fabrice Brunet (IsTerre, Université de Grenoble, France), and colleagues at IFPEN in Rueil, France (Virgile Rouchon, Laura Créon then PhD student, Valérie Beaumont, Eric Deville, Julia Guelard PhD student, Christele Vacquand then PhD student,  Olivier Sissmann, Alain Prinzhofer). The CO2 and H2 problematics both require strong geochemical modeling. I have an ongoing collaboration regarding applications of the Chess Code with Jérôme Corvisier and Laurent de Windt (Ecole des Mines de Paris, Fontainebleau) and modeling of stable isotope fractionations by subsurface biomass with Magali Ader (IPG Paris), Bénédicte Ménez (IPG Paris), Caroline Thaler (then PhD at IPG Paris now at MNHN Paris) and Giovanni Aloisi (CNRS, UPMC, Paris). Some ab initio modeling of CO2 and H2 reactivity at mineral surfaces are also required to investigate the difficult question of specific properties in aqueous solutions at the vicinity of mineral surfaces. I participate to this latter research lead by Marco Saitta  and Fabio Pietrucci (IMPMC, Paris).

 Hydrothermal biomineralization - In the years coming, I would like to focus on one single research projet in which I wish to apply the multiple skills acquired and mentioned above. This new project is entitled : « Biomineralization in Hydrothermal Conditions by Hyperthermophilic Microoganisms ». It has fundamental ambitions such as to determine whether mineral traces of biological activity at high pressure and temperature in hydrothermal systems can actually be identified with important implications for finding new traces of life in the rock record and for the search of auto-organization phenomena in terrestrial and extra-terrestrial samples. It also aims at determining whether mineral phases can inform us about the biodiversity in the hottest parts of these hydrothermal systems, present and past, at investigating the questions of adaptation of life to extreme temperatures and at understanding the mechanistic and ecological meanings of the high temperature limits of life. It also has potential applications such as possible improvement of  hydrothermal synthesis of solids by assistance of hyperthermophilic organisms or gains in bioleaching industrial processes by using hyperthermophilic microorganims. This project will strongly benefit from the proximity of researchers pursuing their own projects at Muséum National d’Histoire Naturelle, particularly Sylvain Bernard (IMPMC, Paris), Adrienne Kish (MCAM, Paris), Jennyfer Miot (IMPMC, Paris) and Laurent Rémusat  (IMPMC, Paris). It will also benefit from appreciated assistance in knowledge of hyperthermophilic organisms by Aurore Gorlas (Université Paris Sud) and Erwan Roussel (IFREMER Brest).



November 2017, on minisabbatical in the group of Dieter Braun in the physics department of Ludwig-Maximilian Universität in Munich, Germany. To work on dynamics of chemical reactions in temperature gradients which is of special interest ot understand the microbiology (and prebiotic chemistry) in natural hydorthermal systems.

Sylvain Bernard - 02/11/17